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Merck Associate Principal Scientist (Computational), Process and Product Modeling for Large Molecules, Merck Manufacturing Division, Remote in Topeka, Kansas

Job Description

New hires based in the US & Puerto Rico will be required to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption or accommodation to this vaccination requirement, subject to applicable law.

Our Manufacturing Operations teams are the people that make our products. We work in the manufacturing plants with a “Safety First, Quality Always” mindset striving for continuous improvement. We work in the local plant connected to our global manufacturing network to ensure the highest quality of raw materials, intermediates and finished products.

The Computational and Digital Sciences group in the Manufacturing Division seeks an Associate Principal Scientist who will develop and utilize advanced computational models to promote the commercialization of large molecules (including biologics, vaccines, and sterile liquids). As a potential candidate, you should have advanced graduate degree (s) in an engineering or scientific discipline with industrial knowledge relevant to modeling of large molecules. Your working knowledge includes modeling and computational sciences applied to large molecules.

In this role, you will build and apply predictive tools for drug substance (upstream and downstream) and drug product manufacturing unit operations using a variety of process-modeling tools. Examples of techniques you may use include computational fluid dynamics (CFD), flowsheet models, population balance modeling, engineering models (mass, momentum, energy transport, chemical/biochemical reaction kinetics, etc.), data motivated models, and other modeling methods.

This position is based in West Point, PA (preferred location), or Kenilworth, NJ, USA.

Roles and Position Tasks

  • Work collaboratively with scientists and engineers to develop end-to-end modeling solutions that will help with commercialization of large molecule manufacturing operations. Examples of problems on which you will work include: scale-up or scale-down, tech-transfer, fluid-flow and multiphase-flow modeling occurring in drug-substance unit operations (bioreactors, mixing vessels, chromatography, filtration) and drug product unit operations (freezing, thawing, mixing, filling), as well as process economic modeling, plant simulation, etc.

  • Direct the development and deployment of computational tools, using a combination of commercial software, open-source tools, and in-house models (that you may have created). Demonstrate creativity in solving complex, physical/biochemical problems faced during industrial manufacturing.

  • Work objectively with minimal supervision. Direct the use of computational techniques on project teams and in the department. Interact directly with project teams to identify modeling opportunities, and propose and execute modeling solutions to complex, experimental problems.

  • Convey effectively with project teams on the status of workstreams; translate modeling results to actual, experimental outcomes in projects. Present at internal and external forums (conferences, publications).

  • Direct external collaborations (with universities, research organizations, etc.). Work objectively with internal and external partners (e.g., CMOs, CDMOs, vendors) to develop novel modeling solutions to promote tech transfer.


Doctoral degree (PhD) with 4-7 years of relevant industry knowledge, or a master’s degree (MS / M.S.) with 8-11 years of relevant industry knowledge.

Degree may be in Chemical Engineering, Biochemical Engineering, Biological Engineering, Mechanical Engineering, Chemistry, Pharmaceutical Engineering, or any other relevant discipline. Research knowledge in a computational specialization.

Knowledge and Skills:

  • Expertise with several computational techniques relevant to large-molecules modeling. Relevant techniques include (but not limited to): computational fluid dynamics (CFD), flowsheet models, population balance modeling (PBM), first-value engineering models (mass, momentum, energy transport, chemical/biochemical reaction kinetics, etc.), process economic modeling, plant simulation, statistical methods, data standard models, numerical methods (be able to setup and solve linear/non-linear equations, ODEs, PDEs, etc.), and other modeling methods.

  • Proficient in programming in at least one standard language: Python, Matlab, C/C++, R, etc.

  • Industrial or relevant research knowledge with large-molecule modalities (biologics, vaccines, sterile liquids) and their manufacturing processes. Expertise in upstream operations, downstream operations, or both.

Preferred Industry Knowledge and Skills:

  • Industrial or academic knowledge with large molecule modalities (biologics, vaccines, and/or sterile liquids) and their manufacturing operations. Knowledgeable of upstream and/or downstream unit operations.

  • History of successful implementation of modeling solutions in the commercialization and cGMP environments is highly desired.

  • high-performance computing industry knowledge.

  • Excellent organization skills and be able to manage multiple projects simultaneously. Excellent stakeholder management skills and ability to work in cross-disciplinary teams. Excellent communication skills, verbal and written. Strong history of publications, presentations, and/or patents

Our Manufacturing & Supply Division is committed to be the most trusted supplier of bio-pharmaceuticals worldwide. Our facilities, along with our external contractors, suppliers, and partners, create an interdependent global manufacturing network that’s committed to delivering a high quality, reliable supply to customers and patients on time, every time.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Current Employees apply HERE (https://wd5.myworkday.com/msd/d/inst/1422$1533/rel-task/3001$14.htmld)

Current Contingent Workers apply HERE (https://wd5.myworkday.com/msd/d/task/1422$4020.htmld)

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (https://survey.sogosurvey.com/r/aCdfqL) if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster (https://www.dol.gov/sites/dolgov/files/ofccp/regs/compliance/posters/pdf/eeopost.pdf)

EEOC GINA Supplement​

OFCCP EEO Supplement (https://www.dol.gov/ofccp/regs/compliance/posters/pdf/OFCCP_EEO_Supplement_Final_JRF_QA_508c.pdf)

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:




VISA Sponsorship:


Travel Requirements:


Flexible Work Arrangements:

Remote Work


Not Indicated

Valid Driving License:


Hazardous Material(s):

Number of Openings:


Requisition ID: R159813